Publications
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2023
Daniel Reumann, Christian Krauditsch, Maria Novatchkova, Edoardo Sozzi, Sakurako Nagumo Wong, Michael Zabolocki, Marthe Priouret, Balint Doleschall, Kaja I. Ritzau-Reid, Marielle Piber, Ilaria Morassut, Charles Fieseler, Alessandro Fiorenzano, Molly M. Stevens, Manuel Zimmer, Cedric Bardy, Malin Parmar & Jürgen A. Knoblich
In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain–striatum–cortex assembloids OPEN ACCESS
Nature Methods (2023). 5 December 2023.
Agnete Kirkeby, Jenny Nelander, Deirdre B. Hoban, Nina Rogelius, Hjalmar Bjartmarz, Novo Nordisk Cell Therapy R&D, Petter Storm, Alessandro Fiorenzano, Andrew F. Adler, Shelby Vale, Janitha Mudannayake, Yu Zhang, Tiago Cardoso, Bengt Mattsson, Anne M. Landau, Andreas N. Glud, Jens C. Sørensen, Thea P. Lillethorup, Mark Lowdell, Carla Carvalho, Owen Bain, Trinette van Vliet, Olle Lindvall, Anders Björklund, Bronwen Harry, Emma Cutting, Håkan Widner, Gesine Paul, Roger A. Barker, and Malin Parmar
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD OPEN ACCESS
Cell Stem Cell. Volume 30, Issue 10, 5 October 2023
Roberta Schellino, Dario Besusso, Roberta Parolisi, Gabriela B. Gómez-González, Sveva Dallere, Linda Scaramuzza, Marta Ribodino, Ilaria Campus, Paola Conforti, Malin Parmar, Marina Boido, Elena Cattaneo, and Annalisa Buffo
hESC-derived striatal progenitors grafted into a Huntington’s disease rat model support long-term functional motor recovery by differentiating, self-organizing and connecting into the lesioned striatum OPEN ACCESS
Stem Cell Res Ther. 2023; 14: 189. Published online 2023 Jul 28
Jana Rájová, Marcus Davidsson, Martino Avallone, Morgan Hartnor, Patrick Aldrin-Kirk, Tiago Cardoso, Sara Nolbrant, Annelie Mollbrink, Petter Storm, Andreas Heuer, Malin Parmar, Tomas Björklund
Deconvolution of spatial sequencing provides accurate characterization of hESC-derived DA transplants in vivo OPEN ACCESS
Mol Ther Methods Clin Dev. 2023 Jun 8; 29
Jessica Giacomoni, Mette Habekost, Efrain Cepeda-Prado, Bengt Mattsson, Daniella Rylander Ottosson, Malin Parmar, Janko Kajtez
Protocol for optical clearing and imaging of fluorescently labeled ex vivo rat brain slices OPEN ACCESS
CellPress. Volume 4, Issue 1, 17 March 2023
Bengt Mattsson, Malin Parmar, Anders Björklund
Athymic Nude Rat Brain Atlas
Elsevier. 1st Edition - June 1, 2023. ISBN: 9780323997409
2022
Birtele M, Storm P, Sharma Y, Kajtez J, Wahlestedt JN, Sozzi E, Nilsson F, Stott S, He XL, Mattsson B, Ottosson DR, Barker RA, Fiorenzano A, Parmar M.
Single-cell transcriptional and functional analysis of dopaminergic neurons in organoid-like cultures derived from human fetal midbrain
Development. 2022 Oct 28
Sozzi E, Kajtez J, Bruzelius A, Wesseler MF, Nilsson F, Birtele M, Larsen NB, Ottosson DR, Storm P, Parmar M, Fiorenzano A.
Silk scaffolding drives self-assembly of functional and mature human brain organoids OPEN ACCESS
Front Cell Dev Biol. 2022 Oct 14
Janelle Drouin-Ouellet, Emilie M Legault, Fredrik Nilsson, Karolina Pircs, Julie Bouquety, Florence Petit, Shelby Shrigley, Marcella Birtele, Maria Pereira, Petter Storm, Yogita Sharma, Andreas Bruzelius, Romina Vuono, Malin Kele, Thomas B Stoker, Daniella Rylander Ottosson, Anna Falk, Johan Jakobsson, Roger A Barker, Malin Parmar
Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson's disease OPEN ACCESS
Stem Cell Reports, 2022 Oct 11
Anders Björklund, Fredrik Nilsson, Bengt Mattsson, Deirdre B Hoban, Malin Parmar
A Combined α-Synuclein/Fibril (SynFib) Model of Parkinson-Like Synucleinopathy Targeting the Nigrostriatal Dopamine System OPEN ACCESS
J Parkinsons Dis, 2022 Sep 26
Sozzi E, Nilsson F, Kajtez J, Parmar M, Fiorenzano A.
Generation of Human Ventral Midbrain Organoids Derived from Pluripotent Stem Cells. OPEN ACCESS
Current protocols. 2022 Sep.
Parmar M
Targets for astrocyte-based treatments of Parkinson's disease (PD) OPEN ACCESS
Proc Natl Acad Sci U S A. 2022 Jul 26
Kajtez J, Wesseler M F, Birtele M, Khorasgani F R, Rylander Ottosson D, Heiskanen A, Kamperman T, Leijten J, Martínez-Serrano A, Larsen N B, Angelini T E, Parmar M, Lind J U, Emnéus J
Embedded 3D Printing in Self-Healing Annealable Composites for Precise Patterning of Functionally Mature Human Neural Constructs OPEN ACCESS
Advanced Science. 16 June 2022
Alekseenko Z, Dias JM, Adler AF, Kozhevnikova M, van Lunteren JA, Nolbrant S, Jeggari A, Vasylovska S, Yoshitake T, Kehr J, Carlén M, Alexeyenko A, Parmar M, Ericson J
Robust derivation of transplantable dopamine neurons from human pluripotent stem cells by timed retinoic acid delivery OPEN ACCESS
Nat Commun. 2022 Jun 1
Elabi OF, Pass R, Sormonta I, Nolbrant S, Drummond N, Kirkeby A, Kunath T, Parmar M, Lane EL
Human Embryonic Stem Cell-Derived Dopaminergic Grafts Alleviate L-DOPA Induced Dyskinesia
Journal of Parkinson's Disease. April 2022
2021
Aldrin-Kirk P, Åkerblom M, Cardoso T, Nolbrant S, Adler AF, Liu X, Heuer A, Davidsson M, Parmar M, Björklund T
A novel two-factor monosynaptic TRIO tracing method for assessment of circuit integration of hESC-derived dopamine transplants OPEN ACCESS
Stem Cell Reports, 2021 Dec 30;17(1):159-172
Alessandro Fiorenzano, Edoardo Sozzi, Marcella Birtele, Janko Kajtez, Jessica Giacomoni, Fredrik Nilsson, Andreas Bruzelius, Yogita Sharma, Yu Zhang, Bengt Mattsson, Jenny Emnéus, Daniella Rylander Ottosson, Petter Storm & Malin Parmar
Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids OPEN ACCESS
Nature Communications 2021, volume 12, Article number: 7302
Karolina Pircs, Janelle Drouin-Ouellet, Vivien Horváth, Jeovanis Gil, Melinda Rezeli, Raquel Garza, Daniela A. Grassi, Yogita Sharma, Isabelle St-Amour, Kate Harris, Marie E. Jönsson, Pia A. Johansson, Romina Vuono, Shaline V. Fazal, Thomas Stoker, Bob A. Hersbach, Kritika Sharma, Jessica Lagerwall, Stina Lagerström, Petter Storm, Sébastien S. Hébert, György Marko-Varga, Malin Parmar, Roger A. Barker, Johan Jakobsson
Distinct subcellular autophagy impairments in induced neurons from Huntington’s disease patients OPEN ACCESS
Brain, 22 December 2021
Johansson P.A., Per Ludvik Brattås P.L., Douse Ch.H., Hsieh PH, Adami A, Pontis J, Grassi D, Garza R, Sozzi E, Cataldo R, Jönsson M.E., Atacho D.A.M., Pircs K, Eren F, Sharma Y, Johansson J, Fiorenzano A, Parmar M, Fex M, Trono D, Eichler E.E.
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development OPEN ACCESS
Cell Stem Cell, 7 oktober 2021
Malin Parmar, Anders Björklund, Tomas Björklund
In vivo conversion of dopamine neurons in mouse models of Parkinson’s disease — a future approach for regenerative therapy?
Current Opinion in Genetics & Development, Volume 70, October 2021, Pages 76-82
Alessandro Fiorenzano, Edoardo Sozzi, Malin Parmar and Petter Storm
Dopamine Neuron Diversity: Recent Advances and Current Challenges in Human Stem Cell Models and Single Cell Sequencing OPEN ACCESS
Cells 2021, 10(6), 1366
Max Brambach, Ariane Ernst, Sara Nolbrant, Janelle Drouin-Ouellet, Agnete Kirkeby, Malin Parmar, Victor Olariu
Neural tube patterning: from a minimal model for rostrocaudal patterning toward an integrated 3D model OPEN ACCESS
iScience, Volume 24, Issue 6, 25 June 2021
Janko Kajtez, Fredrik Nilsson, Alessandro Fiorenzano, Malin Parmar, Jenny Emnéus
3D biomaterial models of human brain disease OPEN ACCESS
Neurochemistry International, Volume 147, July 2021, 105043
Anders Björklund, Malin Parmar
Dopamine Cell Therapy: From Cell Replacement to Circuitry Repair OPEN ACCESS
Journal of Parkinson's Disease, 2021 March 29
Alessandro Fiorenzano, Marcella Birtele, Jenny Nelander Wahlestedt, Malin Parmar
Evaluation of TH-Cre knock-in cell lines for detection and specific targeting of stem cell-derived dopaminergic neurons OPEN ACCESS
Heliyon. 2021 Jan 20
Fredrik Nilsson, Petter Storm, Edoardo Sozzi, David Hidalgo Gil, Marcella Birtele, Yogita Sharma, Malin Parmar, Alessandro Fiorenzano
Single-Cell Profiling of Coding and Noncoding Genes in Human Dopamine Neuron Differentiation OPEN ACCESS
Cells. 2021 Jan 12
2020
Shelby Shrigley, Fredrik Nilsson, Bengt Mattsson, Alessandro Fiorenzano, Janitha Mudannayake, Andreas Bruzelius, Daniella Rylander Ottosson, Anders Björklund, Deirdre B Hoban, Malin Parmar
Grafts Derived from an α-Synuclein Triplication Patient Mediate Functional Recovery but Develop Disease-Associated Pathology in the 6-OHDA Model of Parkinson's Disease OPEN ACCESS
Journal of Parkinson's Disease, 23 December 2020
Nolbrant S, Giacomoni J, Hoban DB, Bruzelius A, Birtele M, Chandler-Militello D, Pereira M
Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons OPEN ACCESS
Stem Cell Reports. 2020 Sep 8
Roussakis AA, Zeng Z, Lao-Kaim NP, Martin-Bastida A, Piccini P, TRANSEURO consortium (incl. Björklund A, Nelander-Wahlestedt J, Parmar M)
Parkinson's disease laterality: a 11 C-PE2I PET imaging study OPEN ACCESS
J Neurol. 2020 Sep 2.
Malin Parmar, Anders Björklund
From Skin to Brain: A Parkinson's Disease Patient Transplanted with His Own Cells
CellStemCell, 2020-07-27
Kajtez J,* Buchmann S, Vasudevan S, Birtele M, Rocchetti S, Pless C J, Heiskanen A, Barker R A, Martínez-Serrano A, Parmar M, Lind J U,* Emnéus J
3D-Printed Soft Lithography for Complex Compartmentalized Microfluidic Neural Devices OPEN ACCESS
Advanced Sicence, 2020, 2001150
Hoban D B, Shrigley S, Mattsson B, Breger L S, Jarl U, Cardoso T, Nelander Wahlestedt J, Luk K C, Björklund A, Parmar M
Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD OPEN ACCESS
PNAS. 15 June 2020.
Anders Björklund, Malin Parmar
Neuronal Replacement as a Tool for Basal Ganglia Circuitry Repair: 40 Years in Perspective OPEN ACCESS
Front. Cell. Neurosci., 29 May 2020
Rifes P, Isaksson M, Singh Rathore G, Aldrin-Kirk P, Knights Møller O, Barzaghi G, Lee J, Lihme Egerod K, Rausch D M, Parmar M, Pers T H, Laurell T & Kirkeby A
Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient
Nature Biotechnology. 2020 May 25.
Tiklová K, Nolbrant S, Fiorenzano A, Björklund Å K, Sharma Y, Heuer A, Gillberg L, Hoban D B, Cardoso T, Adler A F, Birtele M, Lundén-Miguel H, Volakakis N, Kirkeby A, Perlmann T, Parmar M
Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s diseaseOPEN ACCESS
Nature Communications, 2020 May 15.
Besusso D, Schellino R, Boido M, Belloli S, Parolisi R, Conforti P, Faedo A, Cernigoj M, Campus I, Laporta A, Bocchi VD, Murtaj V, Parmar M, Spaiardi P, Talpo F, Maniezzi C, Toselli MG, Biella G, Moresco RM, Vercelli A, Buffo A, Cattaneo E.
Stem Cell-Derived Human Striatal Progenitors Innervate Striatal Targets and Alleviate Sensorimotor Deficit in a Rat Model of Huntington Disease.OPEN ACCESS
Stem Cell Reports. 2020 May 12
Palma-Tortosa S, Tornero D, Grønning Hansen M, Monni E, Hajy M, Kartsivadze S, Aktay S, Tsupykov O, Parmar M, Deisseroth K, Skibo G, Lindvall O, Kokaia Z.
Activity in grafted human iPS cell-derived cortical neurons integrated in stroke-injured rat brain regulates motor behavior. OPEN ACCESS
Proc Natl Acad Sci U S A. 2020 Apr 21
Adler AF, Björklund A, Parmar M.
Transsynaptic tracing and its emerging use to assess graft-reconstructed neural circuits. OPEN ACCESS
Stem Cells. 2020 Feb 26.
Parmar M, Grealish S, Henchcliffe C.
The future of stem cell therapies for Parkinson disease.
Nat Rev Neurosci. 2020 Jan 6
2019
Grassi DA, Brattås PL, Jönsson ME, Atacho D, Karlsson O, Nolbrant S, Parmar M, Jakobsson J.
Profiling of lincRNAs in human pluripotent stem cell derived forebrain neural progenitor cells. OPEN ACCESS
Heliyon. 2019 Dec 31
Davidsson M, Wang G, Aldrin-Kirk P, Cardoso T, Nolbrant S, Hartnor M, Mudannayake J, Parmar M, Björklund T
A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism
PNAS, Dec 9th 2019.
Adler A. F., Cardoso T., Nolbrant S., Mattsson B., Hoban D.B., Jarl U., Nelander Wahlestedt J., Grealish Sh., Björklund A., Parmar M.
hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson’s DiseaseOPEN ACCESS
Cell Reports. VOLUME 28, ISSUE 13, P3462-3473.E5, September 24, 2019
Birtele M, Sharma Y, Kidnapillai S, Lau S, Stoker T, Barker RA, Rylander Ottosson D, Drouin-Ouellet J, Parmar M.
Dual modulation of neuron-specific microRNAs and the REST complex promotes functional maturation of human adult induced neurons. OPEN ACCESS
FEBS Lett. 2019 Sep 19
Barker RA, TRANSEURO consortium.
Designing stem-cell-based dopamine cell replacement trials for Parkinson's disease.
Nat Med. 2019 Jul.
De Luca M, Aiuti A, Cossu G, Parmar M, Pellegrini G, Robey PG.
Advances in stem cell research and therapeutic development.
Nat Cell Biol. 2019 Jun 17
Stacey GN, Andrews PW, Barbaric I, Boiers C, Chandra A, Cossu G, Csontos L, Frith TJ, Halliwell JA, Hewitt Z, McCall M, Moore HD, Parmar M, Panico MB, Pisupati V, Shichkin VP, Stacey AR, Tedesco FS, Thompson O, Wagey R.
Stem cell culture conditions and stability: a joint workshop of the PluriMes Consortium and Pluripotent Stem Cell Platform. OPEN ACCESS
Regen Med. 2019 Apr 2.
Tiklová K, Björklund ÅK, Lahti L, Fiorenzano A, Nolbrant S, Gillberg L, Volakakis N, Yokota C, Hilscher MM, Hauling T, Holmström F, Joodmardi E, Nilsson M, Parmar M, Perlmann T.
Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development.OPEN ACCESS
Nat Commun. 2019 Feb 4;10(1):581.
2018
Voices: Women in Stem Cell Science: Part I OPEN ACCESS
Stem Cell reports. Volume 11, Issue 3, 11 September 2018, Pages 609-612
Henchcliffe C, Parmar M.
Repairing the Brain: Cell Replacement Using Stem Cell-Based Technologies. OPEN ACCESS
J Parkinsons Dis. 2018;8(s1):S131-S137.
Parmar M, Torper O, Drouin-Ouellet J
Cell‐based therapy for Parkinson's disease: A journey through decades towards the light side of the Force OPEN ACCESS
Eur J Neurosci. 2018 Aug 12
Pircs K, Petri R, Madsen S, Brattås PL, Vuono R, Ottosson DR, St-Amour I, Hersbach BA, Matusiak-Brückner M, Hult Lundh S, Petersén Å, Déglon N, Hébert SS, Parmar M, Barker RA, Jakobsson J
Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation OPEN ACCESS
Cell Reports 24, 1397–1406, August 7, 2018
Hagbard L, Cameron K, August P, Penton C, Parmar M, Hay DC, Kallur T
Developing defined substrates for stem cell culture and differentiation.
Philos Trans R Soc Lond B Biol Sci. 2018 Jul 5;373(1750)
Cardoso T, Adler AF, Mattsson B, Hoban DB, Nolbrant S, Wahlestedt JN, Kirkeby A, Grealish S, Björklund A, Parmar M.
Target-specific forebrain projections and appropriate synaptic inputs of hESC-derived dopamine neurons grafted to the midbrain of parkinsonian rats. OPEN ACCESS
J Comp Neurol. 2018 Jul 14.
Barker RA, Götz M, Parmar M.
New approaches for brain repair-from rescue to reprogramming.
Nature. 2018 May
Shrigley S, Pircs K, Barker RA, Parmar M, Drouin-Ouellet J
Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts. OPEN ACCESS
J Vis Exp. 2018 Feb 5;(132).
Parmar M
Towards stem cell based therapies for Parkinson's disease
Development 2018 145. 8 January 2018
2017
Ruetz T, Pfisterer U, Di Stefano B, Ashmore J, Beniazza M, Tian TV, Kaemena DF, Tosti L, Tan W, Manning JR, Chantzoura E, Ottosson DR, Collombet S, Johnsson A, Cohen E, Yusa K, Linnarsson S, Graf T, Parmar M, Kaji K
Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming. OPEN ACCESS
Cell Stem Cell. 2017 Dec 7;21(6)
Avaliani N, Pfisterer U, Heuer A, Parmar M, Kokaia M, Andersson M.
Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus. OPEN ACCESS
Stem Cells International, Volume 2017, 2017 Nov 26
Barker RA, Parmar M, Studer L, Takahashi J
Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease: Dawn of a New Era.
Cell Stem Cell. 2017 Nov 2
Lehnen D, Barral S, Cardoso T, Grealish S, Heuer A, Smiyakin A, Kirkeby A, Kollet J, Cremer H, Parmar M, Bosio A, Knöbel S.
IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells. OPEN ACCESS
Stem Cell Reports. 2017 Oct 10
Drouin-Ouellet J, Pircs K, Barker RA, Jakobsson J, Parmar M.
Direct Neuronal Reprogramming for Disease Modeling Studies Using Patient-Derived Neurons: What Have We Learned? OPEN ACCESS
Front Neurosci. 2017 Sep 28
Kikuchi T, Morizane A, Doi D, Magotani H, Onoe H, Hayashi T, Mizuma H, Takara S, Takahashi R, Inoue H, Morita S, Yamamoto M, Okita K, Nakagawa M, Parmar M, Takahashi J.
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.
Nature. 2017 Aug 30
Nolbrant S, Heuer A, Parmar M, Kirkeby A
Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation.
Nature Protocols 12, Published online 31 August 2017
Pereira M, Birtele M, Shrigley S, Benitez JA, Hedlund E, Parmar M, Ottosson DR.
Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons. OPEN ACCESS
Stem Cell Reports. 2017 Aug 22.
Moraghebi R, Kirkeby A, Chaves P, Rönn RE, Sitnicka E, Parmar M, Larsson M, Herbst A, Woods NB
Term amniotic fluid: an unexploited reserve of mesenchymal stromal cells for reprogramming and potential cell therapy applications. OPEN ACCESS
Stem Cell Res Ther. 2017 Aug 25
Drouin-Ouellet J, Lau S, Brattås PL, Rylander Ottosson D, Pircs K, Grassi DA, Collins LM, Vuono R, Andersson Sjöland A, Westergren-Thorsson G, Graff C, Minthon L, Toresson H, Barker RA, Jakobsson J, Parmar M
REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways. OPEN ACCESS
EMBO Mol Med. 2017 Jun 23.
Kirkeby A, Parmar M, Barker R.A.
Strategies for bringing stem cell-derived dopamine neurons to the clinic: A European approach (STEM-PD)
Science Direct, 7 February 2017
Tornero D, Tsupykov O, Granmo M, Rodriguez C, Grønning-Hansen M, Thelin J, Smozhanik E, Laterza C, Wattananit S, Ge R, Tatarishvili J, Grealish S, Brüstle O, Skibo G, Parmar M, Schouenborg J, Lindvall O, Kokaia Z.
Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli.
Brain. 2017 Jan 22.
Brattås PL, Jönsson ME, Fasching L, Nelander Wahlestedt J, Shahsavani M, Falk R, Falk A, Jern P, Parmar M, Jakobsson J
TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells OPEN ACCESS
Cell Reports. January 3rd, 2017
2016
Pfisterer U, Ek F, Lang S, Soneji S, Olsson R, Parmar M.
Small molecules increase direct neural conversion of human fibroblasts OPEN ACCESS
Sci Rep. 2016 Dec 5
Grealish S, Parmar M.
Plug and Play Brain: Understanding Integration of Transplanted Neurons for Brain Repair.
Cell Stem Cell. 2016 Dec 1
Kirkeby A, Nolbrant S, Tiklova K, Heuer A, Kee N, Cardoso T, Rylander Ottosson D, Lelos M.J, Rifes P, Dunnett S.B, Grealish S, Perlmann T, Parmar M
Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson’s Disease OPEN ACCESS
Cell Stem Cell, 27 October 2016
Kee N, Volakakis N, Kirkeby A, Dahl L, Storvall H, Nolbrant S, Lahti L, Björklund Å.K, Gillberg L, Joodmardi E, Sandberg R, Parmar M, Perlmann T
Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages
Cell Stem Cell, 27 October 2016
Heuer A, Kirkeby A, Pfisterer U, Jönsson ME, Parmar M.
hESC-derived neural progenitors prevent xenograft rejection through neonatal desensitisation. OPEN ACCESS
Exp Neurol. 2016 Aug; 282: 78-85.
Williams DJ, Archer R, Archibald P, Bantounas I, Baptista R, Barker R, Barry J, Bietrix F, Blair N, Braybrook J, Campbell J, Canham M, Chandra A, Foldes G, Gilmanshin R, Girard M, Gorjup E, Hewitt Z, Hourd P, Hyllner J, Jesson H, Kee J, Kerby J, Kotsopoulou N, Kowalski S, Leidel C, Marshall D, Masi L, McCall M, McCann C, Medcalf N, Moore H, Ozawa H, Pan D, Parmar M, Plant AL, Reinwald Y, Sebastian S, Stacey G, Thomas RJ, Thomas D, Thurman-Newell J, Turner M, Vitillio L, Wall I, Wilson A, Wolfrum J, Yang Y, Zimmerman H.
Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform OPEN ACCESS
Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015.
Regen Med. 2016 Jul;11(5):483-92.
Aldrin-Kirk P, Heuer A, Wang G, Mattsson B, Lundblad M, Parmar M, Björklund T.
DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor. OPEN ACCESS
Neuron. 2016 Jun 1;90(5):955-68.
Barker RA, Parmar M, Kirkeby A, Björklund A, Thompson L, Brundin P.
Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016? OPEN ACCESS
J Parkinsons Dis. 2016;6(1):57-63.
2015
Chen G, Wernig M, Berninger B, Nakafuku M, Parmar M, Zhang C-L
In Vivo Reprogramming for Brain and Spinal Cord Repair OPEN ACCESS
eNeuro, October 8th, 2015
Jönsson ME, Nelander Wahlestedt J, Åkerblom M, Kirkeby A, Malmevik J, Brattaas PL, Jakobsson J, Parmar M
Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor OPEN ACCESS
Development. 2015 Sep 15;142(18):3166-77.
Barker RA, Drouin-Ouellet J, Parmar M
Cell-based therapies for Parkinson disease-past insights and future potential
Nat Rev Neurol. 2015 Aug 4.
Torper O, Ottosson DR, Pereira M, Lau S, Cardoso T, Grealish S, Parmar M
In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry OPEN ACCESS
Cell Rep. 2015 Jul 21;12(3):474-81.
Grealish S, Heuer A, Cardoso T, Kirkeby A, Jönsson M, Johansson J, Björklund A, Jakobsson J, Parmar M
Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons OPEN ACCESS
Stem Cell Reports. 2015 Jun 9;4(6):975-83
2014
Lau S, Ryllander Ottosson D, Jakobsson J, Parmar M
Direct Neural Conversion from Human Fibroblasts Using Self-Regulating and Nonintegrating Viral Vectors OPEN ACCESS
Cell Reports, Volume 9, Issue 5, p1673–1680, 11 December 2014
Grealish S, Diguet E, Kirkeby A, Mattsson B, Heuer A, Bramoulle Y, Van Camp N, Perrier A.L., Hantraye P, Björklund A, Parmar M
Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson’s Disease OPEN ACCESS
Cell Stem Cell, Volume 15, Issue 5, 6 November 2014, Pages 653–665
Pereira M, Pfisterer U, Rylander D, Torper O, Lau S, Lundblad M, Grealish S, Parmar M
Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain OPEN ACCESS
Scientific Reports 4, Published 11 September 2014
Parmar M, Hug K , Bjartmarz H , Jakobssen J, Hermeren G and Paul G.
Novel cell therapies for Parkinson’s disease
ACNR 2014;14(3):26-8.
Doi D, Samata B, Katsukawa M, Kikuchi T, Morizane A, Ono Y, Sekiguchi K, Nakagawa M, Parmar M, Takahashi J
Isolation of human induced pluripotent stem cell-derived dopaminergic progenitors by cell sorting for successful transplantation OPEN ACCESS
Stem Cell Reports. 2014 Mar 6;2(3):337-50.
Iovino M, Pfisterer U, Holton JL, Lashley T, Swingler RJ, Calo L, Treacy R, Revesz T, Parmar M, Goedert M, Muqit MM, Spillantini MG.
The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons OPEN ACCESS
Acta Neuropathol. 2014 Feb;127(2):283-95.
2013
Nelander J, Grealish S, Parmar M.
Human foetal brain tissue as quality control when developing stem cells towards cell replacement therapy for neurological diseases
NeuroReport, Issue: Volume 24(18), 18 December 2013, p 1025–1030
Rylander D, Bagetta V, Pendolino V, Zianni E, Grealish S, Gardoni F, Di Luca M, Calabresi P, Cenci MA, Picconi B.
Region-specific restoration of striatal synaptic plasticity by dopamine grafts in experimental parkinsonism
Proc Natl Acad Sci U S A. 2013 Nov 12
Torper O, Pfisterer U, Wolf DA, Pereira M, Lau S, Jakobsson J, Björklund A, Grealish S, Parmar M
Generation of induced neurons via direct conversion in vivo OPEN ACCESS
PNAS March 25, 2013
Kirkeby A, Nelander J, Parmar M.
Generating regionalized neuronal cells from pluripotency, a step-by-step protocol OPEN ACCESS
Front Cell Neurosci. 2012;6:64. Epub 2013 Jan 3.
Ribeiro D, Laguna Goya R, Ravindran G, Vuono R, Parish CL, Foldi C, Piroth T, Yang S, Parmar M, Nikkhah G, Hjerling-Leffler J, Lindvall O, Barker RA, Arenas E.
Efficient expansion and dopaminergic differentiation of human fetal ventral midbrain neural stem cells by midbrain morphogens
Neurobiology of Disease, Volume 49, January 2013, Pages 118–127
2012
Kirkeby A, Parmar M
Building authentic midbrain dopaminergic neurons from stem cells - lessons from development
Translational Neuroscience, December 2012, Volume 3, Issue 4, pp 314-319
Cooper O, Parmar M, Isacson O.
Chapter 13 - Characterization and criteria of embryonic stem and induced pluripotent stem cells for a dopamine replacement therapy
Progress in Brain Research. 2012;200:265-76.
Ganat YM, Calder EL, Kriks S, Nelander J, Tu EY, Jia F, Battista D, Harrison N, Parmar M, Tomishima MJ, Rutishauser U, Studer L.
Identification of embryonic stem cell-derived midbrain dopaminergic neurons for engraftment OPEN ACCESS
The Journal of Clinical Inverstigation. Volume 122, Issue 8 (August 1, 2012). 2928–2939
Kirkeby A, Grealish S, Wolf D A, Nelander J, Wood J, Lundblad M, Lindvall O, Parmar M
Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions OPEN ACCESS
Cell Reports, 26 May 2012
Parmar M, Björklund A
Generation of Transplantable Striatal Projection Neurons from Human ESCs OPEN ACCESS
Cell Stem Cell. Volume 10, Issue 4, 6 April 2012, Pages 349–350.
2011
Brundin P, Barker R, and Parmar M
Neural grafting in Parkinson’s disease: problems and possibilities
Progress in Brain Research, 2011 Vol. 184
Kirkeby A, Parmar M, Jakobsson J
Using endogenous microRNA expression patterns to visualize neural differentiation of human pluripotent stem cells
Methods in Molecular Biology, 2011
Grealish S, Jakobsson J, Parmar M.
Lineage reprogramming : A shortcut to generating functional neurons from fibroblasts OPEN ACCESS
Cell Cycle. 2011 Oct 15;10(20):3421-2
Pfisterer U, Wood J, Nihlberg K, Hallgren O, Bjermer L, Westergren-Thorsson G, Lindvall O, Parmar M.
Efficient induction of functional neurons from adult human fibroblasts OPEN ACCESS
Cell Cycle. 2011 Oct 1;10(19).
Malin Parmar, Johan Jakobsson
Turning skin into dopamine neurons OPEN ACCESS
Cell Research, 9 August 2011
Pfisterer U, Kirkeby A, Torper O, Wood J, Nelander J, Dufour A, Björklund A, Lindvall O, Jakobsson J, Parmar M.
Direct conversion of human fibroblasts to dopaminergic neurons OPEN ACCESS
Proc Natl Acad Sci U S A. 2011 Jun 6.
2010
Sachdeva R, Jönsson M, Nelander J, Kirkeby A, Gentner B, Naldini L, Björklund A, Parmar M, Jakobsson J.
Tracking of differentiated neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors
Proc Natl Acad Sci U S A. 2010 Jun 7.
Konstantoulas CJ, Parmar M, Li M .
FoxP1 promotes midbrain identity in embryonic stem cell derived dopamine neurons by regulating Pitx3
J Neurochem. 2010 Feb 19.
2009
Nelander J, Hebsgaard JB, Parmar M.
Organization of the human embryonic ventral mesencephalon
Gene Expr Patterns. 2009 Dec;9(8):555-61.
Hebsgaard JB, Nelander J, Sabelström H, Jönsson M, Stott S, Parmar M.
Dopamine neuron precursors within the developing human mesencephalon show radial glial characteristics
Glia. 2009 Nov 15;57(15):1648-58.
2008
Rogelius N, Hebsgaard JB, Lundberg C, Parmar M.
Reprogramming of neonatal SVZ progenitors by islet-1 and neurogenin-2
Mol Cell Neurosci. 2008 Jul;38(3):453-9.
2007
Parmar M, Li M.
Early specification of dopaminergic phenotype during ES cell differentiation
BMC Dev Biol. 2007 Jul 18;7:86.
Andersson EK, Irvin DK, Ahlsiö J, Parmar M.
Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cells
Exp Cell Res. 2007 Apr 1;313(6):1172-80.
Cacci E, Villa A, Parmar M, Cavallaro M, Mandahl N, Lindvall O, Martinez-Sarrano A, Kokaia Z.
Generation of human cortical neurons from a new immortal fetal neural stem cell line
Exp Cell Res. 2007 Feb 1;313(3):588-601.
Barraud P, Stott S, Møllgård K, Parmar M, Björklund A.
In vitro characterization of a human neural progenitor cell coexpressing SSEA4 and CD133
J Neurosci Res. 2007 Feb 1;85(2):250-9.
2006
Jensen JB, Parmar M.
Strengths and limitations of the neurosphere culture system
Mol Neurobiol. 2006 Dec;34(3):153-61.
Rogelius N, Jenses JB, Lundberg C, Parmar, M.
Retrovirally delivered Islet-1 increases recruitment of Ng2 expressing cells from the postnatal SVZ into the striatum
Experimental Neurology 2006 201(2):388-98.
Andersson E, Jensen JB, Parmar M, Guillemot F, Björklund A.
Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2
Development 2006 133:507-516.
Thompson LH, Andersson E, Jensen JB, Barraud P, Guillemot F, Parmar M, Björklund A.
Neurogenin2 identifies a transplantable dopamine neuron precursor in the developing ventral mesencephalon
Experimental Neurology 2006 198:183-198.
2005
Barraud P, Thompson L, Kirik D, Björklund A, Parmar M.
Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mouse
European Journal of Neuroscience 2005 22:1555-1569.
2004
Jensen JB, Björklund A, Parmar M.
Striatal neuron differentiation from neurosphere-expanded progenitors depends on Gsh2 expression
Journal of Neuroscience 2004, 24:6958-6967.
2003
Skogh C, Parmar M, Campbell.
The differentiation potential of precursor cells from the mouse lateral ganglionic eminence is restricted by in vitro expansion
Neuroscience 2003 120:379-385.
Parmar M, Sjöberg A, Björklund A, Kokaia Z.
Phenotypic and molecular identity of cells in the adult subventricular zone: in vivo and after expansion in vitro
Molecular and Cellular Neuroscience 2003 24:741-752.
Parmar M, Skogh C, Englund U.
A transplantation study of expanded human embryonic forebrain precursors: evidence for selection of a specific progenitor population
Molecular and Cellular Neuroscience 2003 23:531-543.
2002
Parmar M, Skogh C, Björklund A, Campbell K.
Regional specification of neurosphere cultures derived from subregions of the embryonic telencephalon
Molecular and Cellular Neuroscience 2002, 21:645-656.
2000
Toresson H, Parmar M, Campbell K.
Expression of Meis and Pbx genes and their protein products in the developing telencephalon: implications for regional differentiation
Mechanisms of Development (MoD) 2000;94:183-187.